The frontier of anti-aging science is undergoing rapid transformation with breakthroughs in stem cell and senolytic research. Mesenchymal stem cells (MSCs), with their regenerative and anti-inflammatory properties, are at the forefront of rejuvenative treatments—potentially reversing cellular aging and restoring tissues. Meanwhile, senolytics —a class of molecules targeting and eliminating senescent (“zombie”) cells—are being explored for their ability to mitigate chronic inflammation and age-related degeneration. AI-driven discovery is accelerating senolytic candidate identification, and early trials hint at meaningful healthspan extension. Though clinical application remains nascent, these innovations signal a paradigmshift—shifting aging from inevitability to treatable biological decline.